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North America Protein A Resins Market Size By Product (Natural Protein A, Recombinant Protein A), By Matrix Type (Agarose-based Matrix, Glass or Silica Gel-based Matrix, Organic Polymer-based Matrix), By Application (Immunoprecipitation, Antibody Purification), By End-use (Biopharmaceutical Companies, Clinical Research Laboratories, Academic Research Institutes, Contract Research Organizations), Industry Analysis Report, Regional Outlook (U.S., Canada), Application Potential, Competitive Market Share & Forecast, 2020 - 2026

Published Date: February 2020 | Publisher: Graphical Research Report ID: GR1279 | Delivery : PDF

Industry Trends

North America Protein A Resins Market Share was valued at USD 233.0 million in 2019 and is expected to witness 8.8% CAGR from 2019 to 2026.

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Growth in spending on research and development activities for new drug development will increase the demand of protein A resins in the region. Adoption of chromatography using protein A resin has been used for capturing monoclonal antibodies (mAb) in most of the drug discovery and approval procedures. Developments in protein A during the past years such as increasing its productivity, capacity, and operational velocity has further increased its use in drug development. Additionally, with expanding number of people suffering from chronic diseases, investment in drug discovery will subsequently rise, thereby augmenting the market size.

Rising use of chromatography techniques in chemical and biological disciplines will stimulate North America protein A resins industry growth. Chromatography is commonly used in identification of chemicals and biochemicals and for the separating biological compounds. Due to broad range of benefits offered by chromatography as compared to conventional techniques, its adoption is increasing rapidly. Protein A resin is the most regularly used affinity resin for biomanufacturing and has become the standard technique for capturing recombinant mAb. High superiority and reliability of chromatography will thus drive protein A resins market size in the forthcoming years.

North America Market, By Application

Based on application, the segments analyzed in this report include immunoprecipitation and antibody purification. Immunoprecipitation (IP) application segment held around USD 51.5 million revenue in 2019. The use of immunoprecipitation in research and development for purification of proteins is significantly growing. IP is accurate and effective method for analytical separation of target antigens from crude cell lysates. Moreover, protein A resin plays a vital role in IP for the removal of immune complexes formed between an antigen and its specific antibody. Thus, with growing application of immunoprecipitation, the segment will witness robust growth.

North America Market, By Product

Based on product, the protein A resins market systems market comprises of natural protein A resins and recombinant protein A resins. Recombinant protein A segment is forecast to progress at over 8.5% CAGR during the analysis period. Use of protein tag fused with recombinant protein enables better purification and detection. Recombinant proteins are used for diagnosis, vaccines, therapeutic proteins, and functional enzymes. Furthermore, widespread use of recombinant protein A as affinity ligand will spur the segmental size in the future.

North America Market, By Matrix Type

Based on matrix type, the segments analyzed in this report include Agarose-based matrix, Glass or silica gel-based matrix and organic polymer-based matrix. Agarose-based matrix segment held more than 80% revenue share in 2019. Cross-linked agarose is very popular matrix due to its favourable pH range. Agarose beads are prone to pressure and absolute to robust support, such as silica, polystyrene and other highly cross-linked materials. This media meets the standards for laboratory as well as large-scale applications. Such benefits will aid in robust segmental growth.

North America Market, By End-use

On the basis of end-use, the market is segmented as biopharmaceutical companies, clinical research laboratories, academic research institutes, and contract research organizations. Application of protein A resins in biopharmaceutical companies will foresee 8.7% CAGR in the forecast timeframe. Expansion in number of biotechnology and pharmaceutical firms coupled with increasing R&D activities will be the chief factors responsible for segment growth. Protein A resins are used by biopharmaceutical firms for large-scale purification of mAbs. Protein A resin is thoroughly investigated and well characterized to support final approval of biopharmaceuticals before it is released to the healthcare market. Additionally, these resins can be reused. Thus, frequent use and cost-effectivity will increase the demand for protein A resins in biopharmaceutical companies in coming years.

North America Market, By Country

U.S. protein A resins market accounted for about 85% revenue share of the North American Protein A Resins market in 2019. Increasing technological developments and huge R&D in genomic studies will provide considerable traction to market growth. Also, several initiatives by the scientific associations and institutes to ensure effective manufacturing of protein therapeutics will impe the market growth in the country.

Competitive Market Share

Some of the major industry players involved in North America protein A resins market include GE Healthcare, Thermo Fisher Scientific, EMD Millipore, and Bio-Rad Laboratories among other market players. These companies are adopting strategies such as product differentiation and launch to garner significant market share in the industry. For instance, in September 2017, GE hEalthcare announced the introduction of a novel protein A resin, MabSelect PrismA. The launch aimed at expansing the firm’s business and customer base.

North America Protein A Resins Industry Background

Protein A resins have been developed continuously since the past forty years. Orthoclone, that was the first therapeutic antibody, utilized Protein A chromatography for its purification more than 30 years ago. Protein A was later used for capturing monoclonal antibodies in most  of FDA submissions. sSingificant advances have been made in protein A resins by established players and new entrants since its introduction. They have now become the golden standard for mAb purification and has grown remarkably due to its exceptional performance and capacities. Variations of Protein A ligands and alternatives including monolith membranes and microshperes were also verified to improve purification performance. With continuously increasing number of biotechnology firms, the adoption of chromatography and thus protein A resins will grow rapidly in the foreseeable future.

Frequently Asked Question(FAQ) :

North America Protein A Resins Market Share to Propel at 8.8% CAGR to 2026.
North America Protein A Resins Market is Segmented on basis of Product, Matrix Type, Application & End-use.
Some of the major industry players involved in North America protein A resins market include GE Healthcare, Thermo Fisher Scientific, EMD Millipore, and Bio-Rad Laboratories among other market players.

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North America Protein A Resins Market (2020-2026) | Prospects & Strategies


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